| Unlockable: | How to Unlock: |
| Abomination | Defeat Abomination. |
| Grey Hulk | Smash 10,000 objects. |
| Hulkbuster Iron Man | Have a saved game file from Iron Man. |
| Ironclad | Defeat the U-Foes, trick a U-Foe into KOing his teammate; or defeat Abomination. |
| Maestro | Destroy a building in each neighborhood. |
| Professor Hulk (Smart Hulk) | Complete all jump challenges. |
| Savage Hulk | Collect five comic book covers. |
